学術業績

代表的 原書論文

2010(平成22)年 Tada Y, et al.: Characterization of Cardiac Size and Function in SHRSP.Z-Lepr(fa)/IzmDmcr Rats, a New Animal Model of Metabolic Syndrome.
Biol. Pharm. Bull. 33(12):1971-6, 2010.
2008(平成20)年 Hayashi N, Koshiba M, Nishimura K, Sugiyama D, Nakamura T, Morinobu S, Kawano S, Kumagai S: Prevalence of disease-specific antinuclear antibodies in general population: estimates from annual physical examinations of residents of a small town over a 5-year period.
Mod. Rheumatol. 18(2):153-160, 2008.
2007(平成19)年 Nishimura K, Sugiyama D, Kogata Y, Tsuji G, Nakazawa T, Kawano S, Saigo K, Morinobu A, Koshiba M, Kuntz KM, Kamae I, Kumagai S: Meta-analysis: diagnostic accuracy of anti-cyclic citrullinated peptide antibody and rheumatoid factor for rheumatoid arthritis.
Ann. Intern. Med. 146(11):797-808, 2007.
2006(平成18)年 Tsuji G, Koshiba M, Nakamura H, Kosaka H, Hatachi S, Kurimoto C, Kurosaka M, Hayashi Y, Yodoi J, Kumagai S: Thioredoxin protects against joint destruction in a murine arthritis model.
Free Radic. Biol. Med. 40(10): 1721-1731, 2006.
2004(平成16)年 Koshiba M, Nakamachi Y, Kosaka H, Nakazawa T, Tsuji G, Kumagai S: Modification of cytokine milieu by A2A adenosine receptor-signaling - possible application for inflammatory diseases.
Nucleosides Nucleotides Nucleic Acids 23(8 & 9): 1101-1106, 2004.
2003(平成15)年 Nakamachi Y, Koshiba M, Nakazawa T, Hatachi S, Saura R, Kurosaka M, Kusaka H, Kumagai S: Specific increase in enzymatic activity of adenosine deaminase 1 in rheumatoid synovial fibroblasts.
Arthritis Rheum. 48(3): 668-674, 2003.
  Kosaka H, Koshiba M, Nakazawa T, Tsuji G, Saegusa J, Kanagawa S, Saura R, Kurosaka M, Yoshino S, Kumagai S: Inhibition of the nucleoside transporter inhibits disease progression in the rat adjuvant-induced arthritis model.
Drug Dev. Res.58(4): 479-485, 2003.
  Nakazawa T, Koshiba M, Kosaka H, Tsuji G, Nakamachi Y, Saura R, Kurosaka M, Tanaka Y, Kumagai S: Adenosine downregulates cytokine-induced expression of intercellular adhesion molecule-1 on rheumatoid synovial fibroblasts independently of adenosine receptor signaling.
Drug Dev. Res. 58(4): 368-376, 2003.
  Hatachi S, Iwai Y, Morinobu S, Kawano S, Kobayashi M, Koshiba M, Saura R, Kurosaka M, Honjo T, Kumagai S: CD4+PD-1+T cells accumulate as unique anergic cells in synovial fluid from rheumatoid arthritis patients.
J. Rheumatol. 30(7): 1410-1419, 2003.
2002(平成14)年 Koshiba M, Kosaka H, Nakazawa T, Hayashi N, Saura R, Kitamura N, Kumagai S: 2-Chloroadenosine but not adenosine induces apoptosis in rheumatoid fibroblasts independently of cell surface adenosine receptor signalling.
British J. Pharmacol., 135 (6):1477-1486, 2002.
1999(平成11)年 Koshiba M, Rosin DL, Hayashi N, Linden J, Sitkovsky MV: Patterns of A2A extracellular adenosine receptor expression in different functional subsets of human peripheral T cells. Flow cytometry studies with anti-A2A receptor monoclonal antibodies.
Mol. Pharmacol. 55 (3): 614-624, 1999.
  Hayashi N, Kawamoto T, Mukai M, Morinobu A, Koshiba M, Kondo S, Maekawa S, Kumagai S: Detection of antinuclear antibodies by use of an enzyme immunoassay with nuclear HEp-2 cell extract and recombinant antigens: comparison with immunofluorescence assay in 307 patients.
Clin. Chem. 47 (9): 1649-1659, 2001.
  Yamamichi H, Kasakura S, Yamamori S, Iwasaki R, Jikimoto T, Kanagawa S, Ohkawa J, Kumagai S, Koshiba M: Creatine kinase gene mutation in a patient with muscle creatine kinase deficiency.
Clin. Chem. 47 (11): 1967-1973, 2001.
1997(平成9)年 Huang S, Apasov SG, Koshiba M, Sitkovsky M: Role of A2A extracellular adenosine receptor-mediated signaling in adenosine-mediated inhibition of T cell activation and expansion.
Blood 90 (4): 1600-1610, 1997.
  Apasov SG, Koshiba M, Chused TM, Sitkovsky MV: Effects of extracellular ATP and adenosine on different thymocyte subsets: possible role of ATP-gated channels and G protein-coupled purinergic receptor.
J. Immunol. 158 (11): 5095-5105, 1997.
  Koshiba M, Apasov S, Sverdlov V, Chen P, Erb L, Turner J, Weisman G, Sitkovsky MV: Transient up-regulation of the expression of p2y2 extracellular ATP purinergic receptors mRNA in activated thymocytes as an immediate early gene response.
Proc. Natl. Acad. Sci., USA 94 (3): 831-836, 1997.
  Koshiba M, Kojima H, Huang S, Apasov SG, Sitkovsky MV: Memory of extracellular adenosine A2A purinergic receptor-mediated signaling in murine T cells.
J. Biol. Chem. 272 (41): 25881-25889, 1997.

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代表的 総説

2004(平成16)年 Sitkovsky MV, Lukashev D, Apasov S, Kojima H, Koshiba M, Caldwell C, Ohta A, Thiel M: Physiological Control of Immune Response and Inflammatory Tissue Damage by Hypoxia-Inducible Factors and Adenosine A2A Receptors.
Ann.Rev.Immunol. 22: 657-682, 2004.
1995(平成7)年 Apasov S, Koshiba M, Redegeld F, Sitkovsky MV: Role of extracellular ATP and P1 and P2 classes of purinergic receptors in T-cell development and cytotoxic T lymphocyte effector functions.
Immunol. Reviews 146: 5-19, 1995.

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代表的 著書

2009(平成21)年 Sitkovsky M, Armstrong J, Koshiba M, Apasov S: Purinoreceptors and T cell function: regulation of lymphocyte activation by extracellular ATP and adenosine.
In Cardiovascular Biology of Purines (eds. Burnstock G, Dobson JG, Liang BT and Linden J). Kluwer Academic Publishers, Boston, MA, pp. 302-311, 1998.
2008(平成20)年 Hayashi N, Kawamoto T, Mukai M, Morinobu A, Koshiba M, Kondo S, Kumagai S: Enzyme immunoassay by mixture of a nuclear hep2 cell extract and recombinant proteins is equally or more useful than immunofluorescence assay for detection of antinuclear antibodies (ANA).
In Autoantigens and autoantibodies: Diagnostic tools and clues to understanding autoimmunity (eds. Conrad K, Humbel RL, Meurer M, Shoenfeld Y, and Tan EM). Pabst Science Publishers, Berlin. pp. 696-697, 2000.

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